How can we reduce chemical pollution burdens in our freshwater systems? Understanding the physical and chemical properties of chemical pollutants has facilitated the development of water purification technologies and water quality protection policies. However, many chemical pollutants such as most pharmaceuticals and some pesticides are chiral compounds that exists as two or more stereoisomers. These stereoisomers often have similar physical and chemical properties but different biological properties. These differences in biological properties have been leveraged in identifying the sources of chemical pollutants found in freshwater systems. Additionally, in pesticides, some stereoisomers are more toxic to the target pest but not non-target organisms and vice-versa. Can using a single stereoisomer reduce pesticide burden in the aquatic environments?