A comprehensive review on tyrosinase inhibitors

Samaneh Zolghadri, Asieh Bahrami, Mahmud Tareq Hassan Khan, J. Munoz-munoz, F. Garcia-molina, F. Garcia-canovas, Ali Akbar Saboury

Research output: Contribution to journalArticlepeer-review

397 Citations (Scopus)
255 Downloads (Pure)


Tyrosinase is a multi-copper enzyme which is widely distributed in different organisms and plays an important role in the melanogenesis and enzymatic browning. Therefore, its inhibitors can be attractive in cosmetics and medicinal industries as depigmentation agents and also in food and agriculture industries as antibrowning compounds. For this purpose, many natural, semi-synthetic and synthetic inhibitors have been developed by different screening methods to date. This review has focused on the tyrosinase inhibitors discovered from all sources and biochemically characterised in the last four decades.
Original languageEnglish
Pages (from-to)279-309
Number of pages31
JournalJournal of Enzyme Inhibition and Medicinal Chemistry
Issue number1
Early online date3 Jan 2019
Publication statusE-pub ahead of print - 3 Jan 2019


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