A metabolomic investigation of the effects of vitamin E supplementation in humans

Max Wong, John Lodge

Research output: Contribution to journalArticlepeer-review

27 Citations (Scopus)
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Background Vitamin E is a nutrient with both antioxidant and non-antioxidant activities and has been shown to modulate the function of a number of cell types in vitro and in human studies. However studies have also shown vitamin E to have detrimental interactions and therefore it is important to establish the extent to which this nutrient influences metabolism. Metabolomics can potentially identify nutrient-metabolism interactions and therefore the aim of this study was to use a non-targeted metabolomic approach to identify changes to the plasma metabolome following vitamin E supplementation in humans. Methods A relatively homogenous healthy adult male population (n = 10) provided a fasting blood sample immediately before and after a 4-week vitamin E supplementation regime (400 mg/d of RRR-α-tocopheryl acetate)) on top of their habitual diet. Plasma samples were analysed for vitamin E and clinical markers. Plasma underwent non-targeted metabolite profiling using liquid chromatography/mass spectroscopy and data was processed using multivariate statistical analysis. Results Plasma vitamin E concentrations were significantly increased following supplementation (p 
Original languageEnglish
Pages (from-to)110
JournalNutrition & Metabolism
Issue number1
Publication statusPublished - 19 Dec 2012


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