Antimicrobial peptides and wound healing: biological and therapeutic considerations

Maria Luisa Mangoni, Alison McDermott, Michael Zasloff

Research output: Contribution to journalArticlepeer-review

211 Citations (Scopus)


Repair of tissue wounds is a fundamental process to re-establish tissue integrity and regular function. Importantly, infection is a major factor that hinders wound healing. Multicellular organisms have evolved an arsenal of host-defense molecules, including antimicrobial peptides (AMPs), aimed at controlling microbial proliferation and at modulating the host's immune response to a variety of biological or physical insults. In this brief review, we provide the evidence for a role of AMPs as endogenous mediators of wound healing and their promising therapeutic potential for the treatment of non-life-threatening skin and other epithelial injuries.
Original languageEnglish
Pages (from-to)167-173
JournalExperimental Dermatology
Issue number3
Early online date6 Jan 2016
Publication statusPublished - Mar 2016


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