Connective tissue diseases: Nucleosomes and systemic sclerosis

Steven O'Reilly, Jacob van Laar

Research output: Contribution to journalBook/Film/Article reviewpeer-review

1 Citation (Scopus)


Systemic sclerosis (SSc) is characterized by an abnormal immune response to innocuous antigens that might lead to autoantibody production. New observations suggest that nucleosomes can mediate both IgG production and B-cell proliferation, via Toll-like receptor signalling, and thereby affect the pathogenesis of SSc.
Refers to Yoshizaki, A. et al. Nucleosome in patients with systemic sclerosis: possible association with immunological abnormalities via abnormal activation of T and B cells. Ann. Rheum. Dis.
Original languageEnglish
Pages (from-to)138-139
JournalNature Reviews Rheumatology
Issue number3
Early online date4 Feb 2016
Publication statusPublished - Mar 2016


Dive into the research topics of 'Connective tissue diseases: Nucleosomes and systemic sclerosis'. Together they form a unique fingerprint.

Cite this