Designing Genetic Feedback Controllers

Andreas W.K. Harris, James A. Dolan, Ciarán L. Kelly, James Anderson*, Antonis Papachristodoulou

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

26 Citations (Scopus)


By incorporating feedback around systems we wish to manipulate, it is possible to improve their performance and robustness properties to meet pre-specified design objectives. For decades control engineers have been successfully implementing feedback controllers for complex mechanical and electrical systems such as aircraft and sports cars. Natural biological systems use feedback extensively for regulation and adaptation but apart from the most basic designs, there is no systematic framework for designing feedback controllers in Synthetic Biology. In this paper we describe how classical approaches from linear control theory can be used to close the loop. This includes the design of genetic circuits using feedback control and the presentation of a biological phase lag controller.

Original languageEnglish
Article number7265107
Pages (from-to)475-484
Number of pages10
JournalIEEE Transactions on Biomedical Circuits and Systems
Issue number4
Publication statusPublished - 14 Aug 2015
Externally publishedYes


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