Experimental design approach for supercritical fluid extraction

Mark Kane, John Dean, Steven Hitchen, Christopher Dowle, Roy Tranter

Research output: Contribution to journalArticlepeer-review

32 Citations (Scopus)


Experimental design with multilinear regression has been used to examine the relative contribution of the main experimental variables during supercritical fluid extraction. Six steroidal compounds of various solubilities in supercritical CO2 were considered. The results indicate that the density of the supercritical fluid has the greatest effect on the solubilisation and transfer of steroid from extraction cell to collection device. The minimum number of cell volumes of supercritical CO2 required for effective extraction was experimentally determined.
Original languageEnglish
Pages (from-to)83-90
JournalAnalytica Chimica Acta
Issue number1
Publication statusPublished - Jan 1993


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