Mitochondrial Homeostasis and Cellular Senescence

Panagiotis V. S. Vasileiou, Konstantinos Evangelou, Konstantinos Vlasis, Georgios Fildisis, Mihalis I. Panayiotidis, Efstathios Chronopoulos, Panagiotis-Georgios Passias, Mirsini Kouloukoussa, Vassilis G. Gorgoulis, Sophia Havaki

Research output: Contribution to journalArticlepeer-review

89 Citations (Scopus)
15 Downloads (Pure)


Cellular senescence refers to a stress response aiming to preserve cellular and, therefore, organismal homeostasis. Importantly, deregulation of mitochondrial homeostatic mechanisms, manifested as impaired mitochondrial biogenesis, metabolism and dynamics, has emerged as a hallmark of cellular senescence. On the other hand, impaired mitostasis has been suggested to induce cellular senescence. This review aims to provide an overview of homeostatic mechanisms operating within mitochondria and a comprehensive insight into the interplay between cellular senescence and mitochondrial dysfunction.
Original languageEnglish
Article number686
Number of pages25
Issue number7
Publication statusPublished - 6 Jul 2019


Dive into the research topics of 'Mitochondrial Homeostasis and Cellular Senescence'. Together they form a unique fingerprint.

Cite this