Molecular-imprinted, polymer-coated quartz crystal microbalances for the detection of terpenes

C. J. Percival*, Simon Stanley, M. Galle, Alan Braithwaite, Michael Newton, Glen McHale, Wayne Hayes

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

108 Citations (Scopus)


A piezoelectric sensor coated with an artificial biomimetic recognition element has been developed for the determination of L-menthol in the liquid phase. A highly specific noncovalently imprinted polymer (MIP) was cast in situ on to the surface of a gold-coated quartz crystal microbalance (QCM) electrode as a thin permeable film. Selective rebinding of the target analyte was observed as a frequency shift quantified by piezoelectric microgravimetry with the QCM. The detectability of L-menthol was 200 ppb with a response range of 0-1.0 ppm. The response of the MIP-QCM to a range of monoterpenes was investigated with the sensor binding menthol in favor of analogous compounds. The sensor was able to distinguish between the D- and L-enantiomers of menthol owing to the enantioselectivity of the imprinted sites. To our knowledge, this is the first report describing enantiomeric resolution within an MIP utilizing a single monomer-functional moiety interaction. It is envisaged that this technique could be employed to determine the concentration of terpenes in the atmosphere.

Original languageEnglish
Pages (from-to)4225-4228
Number of pages4
JournalAnalytical Chemistry
Issue number17
Publication statusPublished - 1 Sept 2001


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