Nocardichelins A and B, new siderophores from Nocardia strain Acta 3026

Kathrin Schneider, Ilona Rose, Sabaratnam Vikineswary, Amanda Jones, Michael Goodfellow, Graeme Nicholson, Winfried Beil, Roderich Süssmuth, Hans-Peter Fiedler

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31 Citations (Scopus)


An actinomycete, strain Acta 3026, isolated from mangrove soil was characterized and found to belong to the genus Nocardia. The strain produces two new cytotoxic metabolites, nocardichelins A (1) and B (2). Each of the compounds strongly inhibited human cell lines from gastric adenocarcinoma, breast carcinoma, and hepatocellular carcinoma with GI50 values in a low micromolar to nanomolar range. The structural characterization of the compounds was performed by mass spectrometry and NMR spectroscopy. The nocardichelins represent a new group of siderophores that combine the structural elements of mycobactin-type siderophores from mycobacteria and hydroxamate-type siderophores (desferrioxamine B) produced by streptomycetes. The chromazurol S assay, characteristic for iron(III) complexation, was positive, confirming the role as a siderophore.
Original languageEnglish
Pages (from-to)932-935
JournalJournal of Natural Products
Issue number6
Publication statusPublished - 2007


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