Prodose adaptive airway device (AAD) nebuliser

David Waters, Ian Hewitt

Research output: Non-textual formArtefact


Waters managed a team of mechanical and electrical engineers, designers and manufactures, working in conjunction with a major USA Rapid Product Development organisation, to design, develop and prototype the Prodose AAD system for Profile Therapeutics PLC. Prodose is a revolutionary, intelligent drug-delivery system for use by patients to deliver an inhaled antibiotic. It was developed to address problems relating to treating asthma, cystic fibrosis and pulmonary hypertension, particularly among young and old patients for whom traditional nebulisers are unsuitable. Prodose Profile's AAD technology has the potential to deliver a wide spectrum of drugs, ranging from interferon through insulin and human growth hormone to painkillers like morphine via the lungs. The unit has a modular approach and a drug loading system for use by patients with a wide variety of abilities and enables patients to charge their nebulizer’s medicine chamber and medicate themselves at will or following a controlled schedule. The main advantage of the unit is that instead of being limited to a factory-pre-set dose, the device utilises a disc containing a microchip and antenna which when inserted into Prodose, controls the patients dosage and monitors data such as drug expiry date. The unit has a clear and intuitive user interface in order to ensure the failsafe use of the device. Waters’ expertise in medical product innovation and knowledge was employed from conceptualisation through to prototyping and specification for manufacture. Waters liaised with specialist electronic, polymer and pharma companies throughout Europe and the USA in order to develop the product. Hewitt was responsible for industrial design direction and communication of technical aspects to the project team. Waters discussed the project at a number of international conferences, including the British Council presentation of British Design, Japan 2003 and the Impact of Design on the Economy, Bangkok, 2007.
Original languageEnglish
PublisherProfile Therapeutics PLC
Publication statusPublished - 4 Sept 2002


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