Reductions in resistance exercise-induced hyperglycaemic episodes are associated with circulating interleukin-6 in Type 1 diabetes

Daniel Turner, Stephen Luzio, Liam Kilduff, Ben Gray, Gareth Dunseath, Stephen Bain, Matthew Campbell, Dan West, Richard Bracken

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11 Citations (Scopus)


To determine the influence of different volumes of resistance exercise on circulating interleukin-6 (IL-6) and to explore the relationships between IL-6 and glycaemia.

Eight participants with complication-free Type 1 diabetes, whose mean +/- SEM age was 38 (6) years, mean +/- SEM HbA1c concentration was 71 +/- 11 mmol/mol (8.7 +/- 1.0%) and mean +/- SEM Type 1 diabetes duration was 15 +/- 13 years, attended the research facility after an overnight fast on four separate occasions, having administered their basal insulin the night before (glargine 27.5 +/- 3.1U, n=8), but omitted morning rapid-acting insulin. Participants completed either a one-set (14-min), two-set (28-min), or three-set (42-min) resistance exercise trial (eight exercises 9 10 repetitions) at 67 +/- 3% one-repetition maximum followed by a 60-min recovery, or a resting control trial. Venous blood samples were taken before and after exercise. Data were analysed using repeated-measures ANOVA (P <= 0.05).

Whereas IL-6 levels remained similar to baseline levels after one set of resistance exercises (30 min, P=0.287; 60 min, P=0.318), IL-6 levels were > baseline levels at 60 min post-exercise after a two-set exercise trial (2.94 +/- 0.94 pg/ml, P=0.002) and doubled at both 30 min (4.01 +/- 1.00 pg/ml, P=0.048) and 60 min (4.28 +/- 1.25 pg/ml, P=0.084) post-exercise after the three-set resistance exercise trial. Post-exercise blood glucose area under the curve (mmol/l/60 min) was greater after both the one-set (P=0.025) and two-set trials (P=0.008), than after the control trial, but similar between the three-set trial and the control trial (P=0.240). The rise in IL-6 from baseline to peak concentration significantly correlated inversely with blood glucose area under the curve (r=-0.65, P=0.041).

Circulating IL-6 is increased by resistance exercise in a volume-dependent manner, and resistance exercise-induced increases in IL-6 correlated with reductions in post-exercise hyperglycaemia in Type 1 diabetes, suggesting a role for IL-6 in improving post-resistance exercise glycaemic disturbances in Type 1 diabetes.
Original languageEnglish
Pages (from-to)1009-1013
Number of pages4
JournalDiabetic Medicine
Issue number8
Early online date25 Apr 2014
Publication statusPublished - Aug 2014


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