SPEAR: Systematic ProtEin AnnotatoR

Matthew Crown, Natalia Teruel, Rafael Najmanovich, Matthew Bashton*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

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We present SPEAR, a lightweight and rapid SARS-CoV-2 variant annotation and scoring tool, for identifying mutations contributing to potential immune escape and transmissibility (ACE2 binding) at point of sequencing. SPEAR can be used in the field to evaluate genomic surveillance results in real-time and features a powerful interactive data visualisation report.

Availability and implementation
SPEAR and documentation are freely available on GitHub: https://github.com/m-crown/SPEAR and is implemented in Python and installable via Conda environment.

Supplementary data are available at Bioinformatics online.
Original languageEnglish
Article numberbtac391
Pages (from-to)3827–3829
Number of pages3
Issue number15
Early online date13 Jun 2022
Publication statusPublished - 1 Aug 2022


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