Within a knowledge-driven, entrepreneurial economy, an increase in a university's importance is observed because of its significant affect on the economy. Thus, entrepreneurship is a phenomenon that could be observed among all university levels: management, academicians, researchers, and undergraduate and postgraduate students. Entrepreneurial universities could produce several externalities in terms of demography, economy, infrastructure, culture, mobility, education, and societal challenges that will later be reflected in productivity, competitive advantages, and regional capacities, networks, identity, and innovation. In this context, entrepreneurial universities have or are positioned to develop innovative pathways to reinforce entrepreneurship in their communities. This chapter explores how entrepreneurial university pathways (education and training) have had an impact on students' start-up intentions and actions. Adopting the institutional economics approach, this research proposes a conceptual model, tested with a sample of 1,759 university students enrolled in three entrepreneurial universities (ITESM, Mexico; UNICAMP, Brazil; and UPC, Chile) in Latin America. Our findings confirm the relevant effect of entrepreneurial university pathways on start-up creation. Not only do the results provide important contributions to the literature, they also provide insights for policy-makers to design policies that further benefit society and educational organizations.